Skip to main content
. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: J Med Chem. 2021 May 18;64(10):6949–6971. doi: 10.1021/acs.jmedchem.1c00491

Scheme 1. Synthesis of Substituted Aromatic Compoundsa.

Scheme 1.

aReagents and conditions: (a) chloroacetyl chloride, K2CO3, DCM, stir, 0–5 °C, 1 h, rt, 3–6 h; (b) piperidinium benzoate, toluene, reflux 3–4 h; (c) DMF, K2CO3, stir 24 h.