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. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: J Med Chem. 2021 May 18;64(10):6949–6971. doi: 10.1021/acs.jmedchem.1c00491

Scheme 2. Synthesis of Substituted Heterocyclic Compoundsa.

Scheme 2.

aReagents and conditions: (a) chloroacetyl chloride, DCM/chloroform, TEA, stir, 0–5 °C, 1 h, rt, 8–12 h; (b) 6-hydroxy naphthaldehyde (3), DMF, K2CO3, stir 36 h; (c) 2,4-thiazolidinedione, methoxy ethanol, piperidine, reflux 3–4 h.