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. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: J Med Chem. 2021 May 18;64(10):6949–6971. doi: 10.1021/acs.jmedchem.1c00491

Scheme 3. Synthesis of Substituted Heteroaryl Compoundsa.

Scheme 3.

aReagents and conditions: (a) chloroacetyl chloride, chloroform, K2CO3, stir, 0–5 °C, 1 h, rt, 24–48 h; (b) 6-hydroxy naphthaldehyde (3), DMF, K2CO3, stir 48 h; (c) 2,4-thiazolidinedione, DMF, piperidine, reflux 3–4 h.