Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose–response curves (DRCs) of indicated inhibitors (A–E) against HDAC4 and (F–H) against HDAC8. Residual enzyme activity of HDAC4 or HDAC8 for compounds 7a–7m (I) and compounds 7n–7y (J) in the presence of 35 μM of the indicated compounds. Data represent means and standard deviations, n = 3. Compounds with less than 40% residual enzyme activity were taken further to determine IC50 values.
