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(A) 3D docking pose of 7l within HDAC8, (B) 2D interactions between 7l and HDAC8. (C) Docked 3D binding pose of 7l within the enlarged binding groove of HDAC4o. (D) 2D interactions between 7l and HDAC4o. Conventional hydrogen bonds are indicated by dotted green lines, alkyl and π-alkyl interactions by dotted magenta or pink lines. A dotted gray line denotes metal binding, whereas a dotted orange line highlights a π-sulfur interaction.
