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. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: J Med Chem. 2021 May 18;64(10):6949–6971. doi: 10.1021/acs.jmedchem.1c00491

Table 3.

PPARγ Transactivation Assay a

graphic file with name nihms-1959306-t0017.jpg
PPARγ
compound Emax%b EC50 μM “Ar” group
7c 13 ± 2 1.220 ± 0.260 4-methylphenyl
7i 22.4 ± 1.8 0.245 ± 0.006 2-bromo-4,6-difluorophenyl
7l 32 ± 3 0.359 ± 0.031 4-bromo-2-methylphenyl
7o 13.0 ± 0.2 0.729 ± 0.027 4-bromophenyl
7r 27 ± 6 0.791 ± 0.025 4-bromo-2-fluorophenyl
7q 8.5 ± 1.5 1.610 ± 0.280 4-nitrophenyl
a

EC50 values with mean ± SD.

b

Efficacy values (Emax) were calculated as a percentage of the maximum obtained fold induction with the reference compounds. All transfection experiments were repeated at least twice in triplicate.