Table 4.
Primary Single Dose DNS Screening of Selected Compounds for Cytotoxicity in a Panel of Seven Cell Lines at 10 μM Concentration a
| % cell death at 10 μM |
|||||||
|---|---|---|---|---|---|---|---|
| compound | CEM | Ramos | HL60 | HeLa | MDA-MB-231 | SH-SY5Y | HS-27 |
| 7c | >40 | >40 | 20.95 | >40 | 22.80 | >40 | 13 |
| 7e | 25.87 | >40 | 19.55 | 39.09 | 5.96 | 0 | >40 |
| 7f | >40 | >40 | 27.58 | 29.68 | 2.84 | 10.79 | 22.56 |
| 7g | >40 | >40 | 0 | >40 | >40 | 0 | 24.69 |
| 7i | >40 | >40 | 12.43 | >40 | >40 | >40 | >40 |
| 7j | 40.24 | >40 | 0 | >40 | >40 | >40 | 0 |
| 7l | 30.82 | 29.78 | 32.90 | >40 | 31 | >40 | 24.90 |
| 7o | 37.44 | 34.53 | 17.64 | >40 | 0 | >40 | 0 |
| 7q | 42.28 | 35.18 | 12.34 | 38.95 | >40 | 0 | 15.32 |
| 7r | >40 | 3.91 | 0 | 0 | 0 | >40 | >40 |
a
CEM: T cell leukemia, Ramos: Burkitt’s B cell lymphoma, HL60: promyelocytic leukemia (myeloblasts), HeLa: cervical adenocarcinoma (epithelial), MDA-MB-231: triple negative breast (epithelial), SH-SY5Y: neuroblastoma (epithelial), HS-27: normal foreskin (fibroblasts).