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. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: J Med Chem. 2021 May 18;64(10):6949–6971. doi: 10.1021/acs.jmedchem.1c00491

Table 5.

CC50 Values of Selected Compounds (7c, 7e, 7f, 7g, 7i, 7j, 7l, 7o, 7q, 7r) and Standard Drugs (SAHA, Pioglitazone) a

compounds cell line CC50 (μM) SCI
7c CEM 2.8 ± 0.31 14.4
Ramos 7.0 ± 1.17 5.8
HeLa 10.3 ± 0.56 3.9
SH-SY5Y 49.5 ± 1.09 0.8
HS-27 40.2 ± 4.75 -
7e Ramos 6.2 ± 0.28 >10
7f CEM 10.6 ± 0.22 >10
Ramos 9.1 ± 0.08 >10
7g CEM 10.7 ± 0.41 >10
Ramos 9.3 ± 0.01 >10
HeLa 10.4 ± 0.58 >10
MDA-MB-231 9.8 ± 0.22 >10
7i CEM 9.6 ± 0.15 4.2
Ramos 9.6 ± 0.14 4.2
HeLa 10.4 ± 0.16 3.8
MDA-MB-231 9.8 ± 0.1 4.1
SH-SY5Y 21.8 ± 0.41 1.8
HS-27 39.9 ± 1.95 -
7j Ramos 10.0 ± 0.39 >10
HeLa 10.2 ± 0.52 >10
MDA-MB-231 10.3 ± 0.12 >10
SH-SY5Y 52.3 ± 3.09 >10
7l HeLa 9.9 ± 0.25 >10
SH-SY5Y 91.1 ± 4.26 >10
7o HeLa 10.1 ± 0.04 >10
7q MDA-MB-231 55.8 ± 1.56 >10
7r CEM 40.9 ± 3.16 1.4
SH-SY5Y 16.0 ± 0.69 3.6
HS-27 57.0 ± 8.45 -
Pioglitazone CEM 0% @ 50 μM -
HeLa 0% @ 10 μM -
SAHA CEM 2.5 ± 0.13 -
HeLa 2.8 ± 1.47 -
a

CC50 reported as average concentration ± std. deviation (μM); SCI = CC50HS‑27/CC50cancer; Nd*-Not determined