Table 4.

Odds ratios for the association between aspirin use and colorectal adenoma stratified by ideal cardiovascular health status.

Aspirin use	Poor cardiovascular health			Intermediate cardiovascular health			Ideal cardiovascular health
	Adenoma cases	Age-adjusted OR (95% CI)	MV-adjusted OR (95% CI)a	Adenoma cases	Age-adjusted OR (95% CI)	MV-adjusted OR (95% CI)a	Adenoma cases	Age-adjusted OR (95% CI)	MV-adjusted OR (95% CI)a
Non-useb	207	1.00 (ref)	1.00 (ref)	585	1.00 (ref)	1.00 (ref)	168	1.00 (ref)	1.00 (ref)
Everc	58	0.70 (0.52–0.95)	0.69 (0.51–0.94)	447	0.87 (0.76–0.99)	0.89 (0.78–1.02)	270	0.87 (0.71–1.06)	0.91 (0.74–1.11)
Age at aspirin initiationd
<60 years	51	0.72 (0.53–0.99)	0.71 (0.52–0.97)	363	0.88 (0.77–1.01)	0.90 (0.78–1.03)	212	0.83 (0.67–1.03)	0.87 (0.70–1.07)
≥60 years	7	0.63 (0.28–1.40)	0.62 (0.28–1.39)	82	0.85 (0.65–1.11)	0.89 (0.68–1.16)	55	1.22 (0.85–1.77)	1.28 (0.89–1.86)

OR, Odds ratio; CI, Confidence interval; MV, Multivariable.

^aOdds ratios adjusted for age (continuous), family history of colorectal cancer (yes, no), smoking status (never, past, current), alcohol consumption (non-current, current, 1–6, current ≥7 drinks/week), vigorous exercise (none, <5, ≥5 hours/week), red meat consumption (quartiles), diabetes (yes, no), and menopausal hormone use (yes, no).

^bNon-users are defined as participants who did not report regular aspirin use during the study period.

^cp_interaction=0.07

^dp_interaction=0.15