Table 5.
Multilevel Modeling – Outcomes for Specific Sleep and Circadian Problems
| Treatment condition effect at PRE | Treatment condition effect at POST | Treatment condition effect at 6FU | |||||||
|---|---|---|---|---|---|---|---|---|---|
| coef. | SE | p | coef. | SE | p | coef. | SE | p | |
| Insomnia (n = 113) | |||||||||
| SDS | −2.26 | 1.42 | 0.11 | −3.47 | 1.52 | 0.02 | −1.60 | 1.51 | 0.29 |
| DSM5 Cross-Cutting Measure | −0.60 | 1.92 | 0.75 | −6.10 | 1.91 | 0.001 | −3.84 | 1.90 | 0.04 |
| PROMIS-SD | −1.07 | 1.32 | 0.42 | −5.79 | 1.38 | <.001 | −4.83 | 1.38 | <.001 |
| PROMIS-SRI | −3.63 | 2.55 | 0.16 | −9.54 | 2.61 | <.001 | −5.17 | 2.59 | 0.046 |
| TST variability - Actigraphy | −7.43 | 15.65 | 0.64 | 6.07 | 18.82 | 0.75 | −2.37 | 18.80 | 0.90 |
| Sleep Health Composite | 0.20 | 0.27 | 0.46 | 0.99 | 0.32 | 0.002 | 0.73 | 0.31 | 0.02 |
| Hypersomnia (n = 85) | |||||||||
| SDS | −1.06 | 1.67 | 0.53 | −3.21 | 1.67 | 0.06 | −0.92 | 1.66 | 0.58 |
| DSM5 Cross-Cutting Measure | 0.62 | 2.37 | 0.79 | −6.08 | 2.28 | 0.008 | −3.32 | 2.26 | 0.14 |
| PROMIS-SD | −0.56 | 1.57 | 0.72 | −5.47 | 1.54 | <.001 | −5.08 | 1.52 | 0.001 |
| PROMIS-SRI | 0.68 | 3.11 | 0.83 | −9.35 | 2.85 | 0.001 | −5.54 | 2.82 | 0.050 |
| TST variability - Actigraphy | 0.52 | 19.80 | 0.98 | −10.56 | 24.26 | 0.66 | 10.36 | 24.18 | 0.67 |
| Sleep health composite | 0.07 | 0.32 | 0.83 | 1.10 | 0.36 | 0.002 | 0.59 | 0.35 | 0.10 |
| Circadian Rhythm Disorders (n = 41) | |||||||||
| SDS | −1.57 | 2.49 | 0.53 | −2.11 | 2.60 | 0.42 | −4.29 | 2.57 | 0.10 |
| DSM5 Cross-Cutting Measure | 1.10 | 3.26 | 0.74 | −5.90 | 3.18 | 0.06 | −3.36 | 3.14 | 0.28 |
| PROMIS-SD | 0.09 | 2.33 | 0.97 | −6.36 | 2.36 | 0.007 | −7.42 | 2.32 | 0.001 |
| PROMIS-SRI | −0.25 | 4.48 | 0.96 | −10.37 | 4.41 | 0.02 | −8.87 | 4.35 | 0.042 |
| TST variability - Actigraphy | −17.64 | 32.91 | 0.59 | 20.18 | 36.72 | 0.58 | 32.34 | 36.23 | 0.37 |
| Sleep health composite | 0.37 | 0.42 | 0.41 | 1.12 | 0.59 | 0.06 | 0.71 | 0.59 | 0.23 |
| Periodic Limb Movement and/or Restless Leg Syndrome (n = 45) | |||||||||
| SDS | −2.33 | 2.39 | 0.33 | −2.06 | 2.27 | 0.36 | −3.23 | 2.20 | 0.14 |
| DSM5 Cross-Cutting Measure | −3.10 | 2.84 | 0.28 | −7.92 | 3.02 | 0.009 | −5.29 | 2.92 | 0.07 |
| PROMIS-SD | −1.86 | 2.27 | 0.41 | −2.98 | 2.29 | 0.19 | −5.05 | 2.22 | 0.02 |
| PROMIS-SRI | −4.29 | 4.60 | 0.35 | −4.34 | 4.26 | 0.31 | −6.90 | 4.12 | 0.09 |
| TST variability - Actigraphy | −2.65 | 26.03 | 0.92 | 29.12 | 30.84 | 0.35 | 4.40 | 29.82 | 0.88 |
| Sleep health composite | 0.29 | 0.44 | 0.51 | 0.30 | 0.54 | 0.59 | 0.88 | 0.53 | 0.10 |
| Parasomnia (n = 57) | |||||||||
| SDS | −3.03 | 1.83 | 0.10 | −2.53 | 1.98 | 0.20 | −1.69 | 1.97 | 0.39 |
| DSM5 Cross-Cutting Measure | −0.93 | 2.48 | 0.71 | −6.10 | 2.81 | 0.03 | −3.97 | 2.80 | 0.16 |
| PROMIS-SD | 0.88 | 1.82 | 0.63 | −8.16 | 1.88 | <.001 | −6.22 | 1.87 | 0.001 |
| PROMIS-SRI | −4.66 | 3.14 | 0.14 | −13.48 | 3.18 | <.001 | −6.81 | 3.17 | 0.032 |
| TST variability - Actigraphy | −1.14 | 19.61 | 0.95 | −5.66 | 25.2 | 0.82 | −39.30 | 24.89 | 0.11 |
| Sleep health composite | −0.12 | 0.34 | 0.72 | 1.48 | 0.40 | <.001 | 0.36 | 0.40 | 0.36 |
Note. Parameters presented are the time-by-treatment interactions, interpreted as the difference between TranS-C+UC relative to UC-DT in mean change from pre-treatment assessment to post-treatment and from pre-treatment assessment to 6FU. PRE = pre-treatment assessment. POST = post-treatment assessment. 6FU = 6-month follow-up assessment. SDS = Sheehan Disability Scale. DSM5 = DSM-5 Cross-Cutting Measure. PROMIS-SD = Patient-Reported Outcomes Measurement Information System–Sleep Disturbance. PROMIS-SRI = Patient-Reported Outcomes Measurement Information System–Sleep-Related Impairment. TST variability – Actigraphy = total sleep time variability measured by actigraphy.