Effect of vRAGE-ELP on skin wound closure in diabetic mice. (A) Photos of wounded areas over time. (B) Percent wound closure analyzed by comparing remaining wound areas with initial wound areas. Diabetic mice treated with vRAGE-ELP showed significantly faster wound closure compared to other groups. N = 8. Statistics: One-way ANOVA followed by Tukey’s test. Asterisks (*) indicate comparisons with fibrin gel control. Plus (+) marks indicate comparisons with vehicle (empty ELP) control. Day 7, * p < 0.05, + p < 0.05. Day 14, ** p < 0.01. Day 21, ** p < 0.01, + p < 0.05. Day 28, * p < 0.05, *** p < 0.001, ++ p < 0.01. Day 35, **** p < 0.0001.