Significant trends for specific factors from the multiplex immunoassay. Results are shown as fold change compared to media baseline (0). Lines within boxes show median values. * denotes significance compared to media and + denotes significance compared to Hp group. # denotes significance between groups in associated brackets. A, Secretion results for a group of four factors that have similar trends: GM-CSF, IL-6, TNF-α, and IL-2. Here, Hp has secretion below media baseline (significant for IL-6). Hb and Hb-Hp have secretion higher than baseline, with Hb typically higher than Hb-Hp. Hb and Hb-Hp are all significantly higher than both media and Hp groups for all factors. B, Secretion results for a group of three factors, MIP-1β, IL-10, and IL-8, in which levels resulting from Hb-Hp are significantly different than Hb treatment