Fig. 1.

Curcumin administration in treatment of leukemia. The apoptosis regulation by curcumin reduces tumorigenesis. Increase in cytochrome c release, upregulation of caspases and cleavage of PARP by curcumin can induce apoptosis. The curcumin derivatives have also shown potential in regulation of apoptosis and autophagy in cancer therapy. Curcumin can be employed with quercetin, canabidiol, piperine and thalidomide in treatment of leukemia. Moreover, polymeric nanoparticles and chitosan nanostructures have delivered curcumin in leukemia therapy.