Fig. 2.

Curcumin use in treatment of lymphoma. The lipid-based nanoparticles are common structures for delivery of curcumin in lymphoma therapy and co-delivery with other compounds such as imatinib. Proliferation suppression and apoptosis acceleration can be obtained through application of curcumin. The upregulation of miR-98 and miR-200 and downregulation of miR-21 and miR-199 mediate the anti-cancer activity of curcumin. Upregulation of Bax and Bad, and release of cytochrome C can mediate apoptosis in tumor cells. Furthermore, cancer metastasis can be reduced due to downregulation of MMP-2 and MMP-9.