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Curcumin administration in treatment of myeloma. The downregulation of STAT3, Akt and Notch3 can significantly reduce the progression of tumor cells. Upregulation of p53 by curcumin induces apoptosis. Moreover, GO-Y030 and GO-Y078 s derivatives of curcumin downregulate IL-6, PI3K/Akt, STAT3 and IRF4 in suppressing tumorigenesis. Moreover, P-gp suppression by curcumin reduces chemoresistance.
