Table 2. Primary and secondary outcome measures before and after 2 weeks of intervention.

Variables		Experimental group (n = 20)			Control group (n = 18)			P value
		Pre-intervention	Post-intervention	P	Pre-intervention	Post-intervention	P
Questionnaires, score
	PSS	25.85 ± 4.97	19.40 ± 4.56	< 0.001***	24.22 ± 5.17	21.22 ± 4.60	0.318	0.037*
	BDI-II	31.70 ± 10.14	17.55 ± 10.58	< 0.001***	29.72 ± 10.09	20.22 ± 8.10	< 0.001***	0.200
	ISI	17.40 ± 5.84	11.45 ± 5.41	0.003**	17.22 ± 5.17	11.83 ± 5.88	0.001**	0.810
	STAI-S	58.45 ± 9.67	46.50 ± 11.45	< 0.001***	55.06 ± 10.83	48.56 ± 7.56	0.002**	0.078
	STAI-T	59.65 ± 10.28	48.50 ± 12.09	0.001**	56.78 ± 9.29	50.44 ± 8.02	< 0.001***	0.132
	PSQI	11.95 ± 3.65	8.50 ± 3.80	0.001**	11.83 ± 3.19	8.33 ± 2.35	< 0.001***	0.963
	WHOQOL	69.70 ± 12.95	76.90 ± 23.12	0.011*	67.61 ± 11.19	73.56 ± 12.23	0.034*	0.833
Blood tests
	IL-6, pg/mL	1.35 ± 0.88	1.37 ± 0.89	0.540	1.20 ± 0.75	1.31 ± 0.87	0.831	0.856
	BDNF, ng/mL	27.21 ± 6.84	24.52 ± 8.60	0.027*	30.46 ± 6.34	25.96 ± 8.62	0.010*	0.318
	TNF-α, pg/mL	0.70 ± 0.22	0.70 ± 0.32	0.354	0.69 ± 0.24	0.67 ± 0.22	0.663	0.730
	Cortisol, μg/dL	8.21 ± 3.47	7.49 ± 3.23	0.442	8.58 ± 2.80	7.02 ± 2.97	0.105	0.529
	ACTH, pg/mL	13.49 ± 5.61	13.18 ± 8.86	0.895	16.41 ± 7.56	14.67 ± 6.01	0.983	0.657

Data are presented as mean ± standard deviation.

PSS = Perceived Stress Scale, BDI-II = Beck Depression Inventory-II, ISI = Insomnia Severity Index, STAI = State-Trait Anxiety Inventory, PSQI = Pittsburgh Sleep Quality Index, WHOQOL = World Health Organization Quality of Life assessment instrument, IL-6 = interleukin-6, BDNF = brain-derived neurotrophic factor, TNF-α = tumor necrosis factor-alpha, ACTH = adrenocorticotropic hormone.

Bold face P values denote statistical significance: ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.