. 2024 Mar 5;44(2):289–302. doi: 10.19852/j.cnki.jtcm.20240203.007

Table 2.

Effect of the method of replenishing Qi and activating blood on step-down test of APP/PS1 double transgenic ischemic mice ($\bar{x}±s$)

Group	Dose (mg·kg^-1·d^-1)	n	Number of errors (times)	Incubation period (s)
C57 sham-operated	-	15	1.3±1.2	226.5±53.1
C57 ischemia	-	15	2.2±1.4^a	179.2±55.3^a
APP/PS1 model	-	14	2.6±1.3	167.7±61.2^a
APP/PS1 ischemia	-	15	3.1±1.7^a	156.8±54.9^a
C57BL ischaemic + aspirin	32	15	1.3±1.3	217.5±64.4
C57BL ischaemic + SLT	32	15	1.2±1.5^b	226.8±66.2^b
APP/PS1 + SLT	32	14	1.5±1.1^c	213.4±49.8^d
APP/PS1 ischaemic + donepezil hydrochloride	20	15	1.5±1.6^c	206.2±73.6^e
APP/PS1 ischaemic + SLT	32	16	1.6±1.5^c	239.5±62.5^e

Notes: ischaemic treatment: both right and left common carotid arteries were separated, and the arterial blood vessel was stimulated with a temperature-controlled current of 80 mu A using an in vivo thrombometer to cause thrombosis. The APP/PS1 ischaemic + donepezil hydrochloride group were administered intragastrically with 20 mg·kg^-1·d^-1 of donepezil hydrochloride. The C57BL ischaemic + aspirin group were administered intragastrically with 32 mg·kg^-1·d^-1 of aspirin, the SLT group were administered intragastrically with 32 mg·kg^-1·d^-1 of SLT and the control group were given 32 mg·kg^-1·d^-1 of solvent. Duration: two months. SLT: Sailuotong; APP: amyloid precursor protein; PS1: presenilin-1presenilin-1.One-way analysis of variance was employed to make comparisons among groups, and in the case of the normal distribution, Tukey’s post hoc test was conducted; otherwise, the Kruskal-Wallis test was adopted. Compared with C57 sham-operated group, ^aP < 0.01; compared with C57 ischemia group, ^bP < 0.05; ^cP < 0.01; compared with APP/PS1 ischemia group, ^dP < 0.05; ^eP < 0.01.