. 2024 Mar 5;44(2):289–302. doi: 10.19852/j.cnki.jtcm.20240203.007

Table 6.

Effect of replenishing Qi and activating blood on VEGF, Aβ_1-42, α7-nAChRs, RAGE and LRP-1 protein content in the brain tissues in APP/PS1 double transgenic ischemic mice of each group ($\bar{x}±s$)

Group	n	VEGF	Aβ_1-42	α7-nAChRs	RAGE	LRP-1
C57 sham-operated	10	1.000±0.172	1.000±0.073	1.000±0.131	1.000±0.074	1.000±0.203
C57 ischemia	10	1.710±0.088^a	0.930±0.122	1.410±0.153^a	1.052±0.091	0.970±0.072
APP/PS1 model	10	0.620±0.045^a	1.550±0.124^d	1.560±0.065^a	1.150±0.116	0.800±0.103
APP/PS1 ischemia	10	0.500±0.046^a	2.730±0.270^a	2.250±0.083^a	1.518±0.077^a	0.600±0.054^d
C57BL ischaemic + aspirin	10	1.330±0.022^b	1.040±0.111	1.380±0.142	1.050±0.062	1.160±0.104 ^f
C57BL ischaemic + SLT	10	1.880±0.042	0.960±0.115	1.110±0.144	1.010±0.052	1.050±0.200
APP/PS1 + SLT	10	1.040±0.081^c	1.200±0.132^c	1.160±0.120^c	1.020±0.079^c	1.260±0.064^c
APP/PS1 ischaemic + donepezil hydrochloride group	10	0.580±0.084	1.560±0.127^c	1.250±0.256^c	1.230±0.075^e	1.180±0.085^c
APP/PS1 ischaemic + SLT	10	0.839±0.095^c	1.460±0.273^c	1.480±0.135^ac	1.240±0.151^ac	1.220±0.032^c

Notes: ischaemic treatment: both right and left common carotid arteries were separated, and the arterial blood vessel was stimulated with a temperature-controlled current of 80 mu A using an in vivo thrombometer to cause thrombosis. The APP/PS1 ischaemic + donepezil hydrochloride group were administered intragastrically with 20 mg·kg^-1·d^-1 of donepezil hydrochloride. The C57BL ischaemic + aspirin group were administered intragastrically with 32 mg·kg^-1·d^-1 of aspirin, the SLT group were administered intragastrically with 32 mg·kg^-1·d^-1 of SLT and the control group were given 32 mg·kg^-1·d^-1 of solvent. Duration: two months. SLT: Sailuotong; APP: amyloid precursor protein; PS1: presenilin-1; VEGF: vascular endothelial growth factor; Aβ_1-42: amyloid-beta1-42; α7-nAChRs: α7-nicotinic acetylcholine receptor; RAGE: anti-receptor for advanced glycation endproducts; LRP-1: lipoprotein receptor-related-protein-1. One-way analysis of variance was employed to make comparisons among groups, and in the case of the normal distribution, Tukey’s post hoc test was conducted; otherwise, the Kruskal-Wallis test was adopted. Compared with C57 sham-operated group, ^aP <0.01, ^dP < 0.05; compared with C57 ischemia group, ^bP < 0.01, ^fP < 0.05; compared with APP/PS1 ischemia group, ^cP < 0.01, ^eP < 0.05.