. 2024 Mar 5;44(2):289–302. doi: 10.19852/j.cnki.jtcm.20240203.007

Table 7.

Effect of replenishing Qi and activating blood on mRNA expressions of VEGF, APP, α7-nAChRs, RAGE and LRP-1 in APP/PS1 double transgenic ischemic mice of each group ($\bar{x}±s$)

Group	n	VEGF	APP	α7-nAChRs	RAGE	LRP-1
C57 sham-operated	10	0.800±0.150	0.720±0.392	1.200±0.291	1.090±0.392	1.160±0.713
C57 ischemia	10	1.450±0.730^a	0.680±5.254	1.120±3.022	0.730±2.991	1.570±0.959^a
APP/PS1 model	10	0.180±0.080^a	1.070±0.045^a	0.190±0.040^a	2.090±0.031^a	0.380±0.191^a
APP/PS1 ischemia	10	0.540±0.481^a	2.730±1.132^a	0.320±0.903^a	2.670±0.675^a	0.850±1.052^a
C57BL ischaemic + aspirin	10	0.860±0.421^b	0.680±5.250	0.400±0.212^d	0.480±0.214^b	1.380±2.053^b
C57BL ischaemic + SLT	10	1.490±0.111	0.150±0.190^d	0.320±0.192^d	0.110±0.091^d	1.250±0.312^c
APP/PS1 + SLT	10	0.630±0.450^c	0.580±0.626	0.700±0.580	0.501±0.455	1.680±0.523^e
APP/PS1 ischaemic + donepezil hydrochloride	10	0.160±0.121	0.420±0.480	0.630±0.002	1.240±0.244	1.490±0.422^e
APP/PS1 ischaemic + SLT	10	0.930±0.345^c	0.690±0.242	1.180±1.591	2.090±0.915	1.420±0.560^e

Notes: ischaemic treatment: both right and left common carotid arteries were separated, and the arterial blood vessel was stimulated with a temperature-controlled current of 80 mu A using an in vivo thrombometer to cause thrombosis. The APP/PS1 ischaemic + donepezil hydrochloride group were administered intragastrically with 20 mg·kg^-1·d^-1 of donepezil hydrochloride. The C57BL ischaemic + aspirin group were administered intragastrically with 32 mg·kg^-1·d^-1 of aspirin, the SLT group were administered intragastrically with 32 mg·kg^-1·d^-1 of SLT and the control group were given 32 mg·kg^-1·d^-1 of solvent. Duration: two months. SLT: Sailuotong; APP: amyloid precursor protein; PS1: presenilin-; VEGF: vascular endothelial growth factor; α7-nAChRs: α7-nicotinic acetylcholine receptor; RAGE: anti-receptor for advanced glycation endproducts; LRP-1: lipoprotein receptor-related-protein-1. One-way analysis of variance was employed to make comparisons among groups, and in the case of the normal distribution, Tukey’s post hoc test was conducted; otherwise, the Kruskal-Wallis test was adopted. Compared with C57 sham-operated group, ^aP < 0.05; compared with C57 ischemia group, ^bP < 0.05, ^dP < 0.01; compared with APP/PS1 ischemia group, ^cP < 0.05, ^eP < 0.01.