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Binding details of QFPDD compounds with HIF-1A (pdb ID: 4h6j).
| Compound | Docking score (kcal/mol) | Hydrogen bond sites of HIF-1A | Hydrophobic interaction sites of HIF-1A |
|---|---|---|---|
| Methylephedrine | −4.7 | Tyr-276 | Tyr-276, Thr-288, His-291, His-292, and Phe-295 |
| Quinic acid | −4.5 | Tyr-276 and His-291 | Phe-295 |
| Pseudoephedrine | −4.4 | Asp-249 | Thr-288, His-291, His-292, and Phe-295 |
| Ephedrine | −4.4 | Asp-249 | Thr-288, His-291, His-292, and Phe-295 |
| Salicylic acid | −4.3 | Thr-288 |
