Table 4.
The association between three tertiles of ferritin and all-cause, CVD, and cancer mortality.
| All-cause mortality | CVD-related mortality | Cancer-related mortality | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. event | HR (95% CI) | p-value | No. event | sHR (95% CI)a | p-value | No. event | sHR (95% CI)a | p-value | |
| Model 1 | |||||||||
| Per SD increment | 231 | 1.02 (0.88–1.18) | 0.793 | 53 | 1.04 (0.77–1.41) | 0.804 | 60 | 0.94 (0.71–1.24) | 0.667 |
| Tertile 1 | 53 | 1.00 (Ref.) | — | 10 | 1.00 (Ref.) | — | 17 | 1.00 (Ref.) | — |
| Tertile 2 | 78 | 1.24 (0.87–1.77) | 0.228 | 19 | 1.36 (0.63–2.97) | 0.438 | 16 | 0.83 (0.42–1.65) | 0.601 |
| Tertile 3 | 100 | 1.29 (0.89–1.87) | 0.173 | 24 | 1.09 (0.49–2.44) | 0.839 | 27 | 1.27 (0.65–2.49) | 0.482 |
| Model 2 | |||||||||
| Per SD increment | 231 | 1 (0.87–1.16) | 0.961 | 53 | 1.09 (0.8–1.49) | 0.581 | 60 | 0.89 (0.68–1.18) | 0.439 |
| Tertile 1 | 53 | 1.00 (Ref.) | — | 10 | 1.00 (Ref.) | — | 17 | 1.00 (Ref.) | — |
| Tertile 2 | 78 | 1.14 (0.8–1.63) | 0.477 | 19 | 1.24 (0.56–2.74) | 0.595 | 16 | 0.82 (0.41–1.64) | 0.574 |
| Tertile 3 | 100 | 1.2 (0.83–1.73) | 0.334 | 24 | 1.15 (0.52–2.57) | 0.727 | 27 | 1.1 (0.56–2.17) | 0.781 |
| Model 3 | |||||||||
| Per SD increment | 231 | 1.09 (0.84–1.43) | 0.519 | 53 | 1.00 (0.55–1.83) | 0.989 | 60 | 0.71 (0.44–1.15) | 0.178 |
| Tertile 1 | 53 | 1.00 (Ref.) | — | 10 | 1.00 (Ref.) | — | 17 | 1.00 (Ref.) | — |
| Tertile 2 | 78 | 1.32 (0.91–1.92) | 0.15 | 19 | 1.19 (0.52–2.70) | 0.681 | 16 | 0.9 (0.43–1.87) | 0.781 |
| Tertile 3 | 100 | 1.55 (0.96–2.51) | 0.077 | 24 | 0.94 (0.33–2.65) | 0.907 | 27 | 1.33 (0.54–3.32) | 0.540 |
Model 1: unadjusted; model 2: adjusted for age, sex, ethnicity, smoking status, drinking status, and education; and model 3: further adjusted for BMI, SBP, DBP, albumin, total cholesterol, serum creatinine, serum potassium, Hemoglobin, MCV, diabetes, hypertension, CVD, cancer, and ferritin.
Sub-distribution hazard ratio accounting for the competing event.