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Variables selected for the preparation of CBD-NLCs
| Factor | Level and code used | ||
|---|---|---|---|
| Low (− 1) | Medium (0) | High (+ 1) | |
| Independent variables | |||
| X1 = Total lipid (% w/v) | 1 | 3 | 5 |
| X2 = Surfactant concentration (%v/v) | 2.5 | 5 | 10 |
| X3 = Ultrasonication time (min) | 4 | 6 | 8 |
| Dependent variables | Constraints | ||
| Y1 = Particle size (nm) | Minimum | ||
| Y2 = PDI | Minimum | ||
