. 2024 Mar 11;16(1):e12564. doi: 10.1002/dad2.12564

TABLE 3.

Risk prediction for 10‐year incidence of NfL positivity for the CAIDE and FRS% individually and after adding sensory and motor functions.

	10‐year Incidence of NfL Positivity ^a
	All ^b		<55 years ^c		≥55 years ^c		Women ^d		Men ^d
	AUC (95% CI)	p	AUC (95% CI)	p	AUC (95% CI)	p	AUC (95% CI)	p	AUC (95% CI)	p
CAIDE	0.68 (0.62, 0.73)	0.002	0.57 (0.48, 0.66)	0.11	0.61 (0.53, 0.69)	0.005	0.73 (0.65, 0.80)	0.02	0.62 (0.53, 0.70)	0.01
CAIDE + Sens‐Motor	0.72 (0.66, 0.77)	0.002	0.61 (0.52, 0.70)	0.11	0.69 (0.62, 0.76)	0.005	0.76 (0.68, 0.83)	0.02	0.68 (0.60, 0.76)	0.01
FRS%	0.69 (0.64, 0.75)	0.10	0.60 (0.51, 0.68)	0.38	0.63 (0.56, 0.71)	0.045	0.72 (0.65, 0.79)	0.47	0.70 (0.62, 0.78)	0.26
FRS% + Sens‐Motor	0.72 (0.67, 0.78)	0.10	0.63 (0.54, 0.71)	0.38	0.70 (0.64, 0.76)	0.045	0.74 (0.67, 0.81)	0.47	0.72 (0.65, 0.80)	0.26

Abbreviations: AUC, area under the receiver operating characteristic curve; CAIDE, Cardiovascular Risk Factors, Aging, and Incidence of Dementia score; CI, confidence interval; FRS, Framingham Risk Score; NfL, neurofilament light chain protein; Sens‐Motor, sensory and motor assessments.

^{^a}

Results of logistic regression models on 10‐year incidence of NfL positivity. p‐Value is the result of a chi‐square test to determine statistically significant differences between AUCs of models including the standard risk score only and models including the standard risk score and additionally sensory and motor measures (hearing impairment, vision impairment, olfactory impairment, grip strength, grooved pegboard test and Short Form Health Survey 36 physical function score).

^{^b}

Sample N = 1417 with 111 cases.

^{^c}

Model stratified by age group. In individuals aged <55 years, sample N = 1026 with 46 cases; in individuals aged ≥55 years, sample N = 391 with 65 cases.

^{^d}

Model stratified by sex. For women, sample N = 765 with 55 cases; for men, sample N = 652 with 56 cases.