TABLE 3.
Results of repeated measures multivariate analyses of variance along with means and standard deviations (in parentheses) for each time of assessment for the sample of adults with Down syndrome having two cycles of assessment prior to developing MCI‐DS.
| Months prior to onset of MCI‐DS | ||||
|---|---|---|---|---|
| Assessment measure total scores | 36 months | 18 months | 0 months | |
| ABSI | 203.2 (30.3) | 200.1 (29.3) | 179.2 (27.8) a | F(2,40) = 29.4, p < 0.00001 |
| DSMSE | 49.2 (11.3) | 46.0 (10.3) a | 39.1 (10.9) a | F(2,35) = 30.3, p < 0.00001 |
| MSRT (Recall) | 18.6 (9.4) | 19.7 (9.5) | 12.3 (7.8) a | F(2,29) = 20.1, p < 0.00001 |
| Block Design | 11.1 (8.6) | 10.3 (9.7) | 6.5 (6.5) a | F(2.35) = 12.8, p < 0.0001 |
| Verbal Fluency | 5.6 (3.2) | 5.8 (3.6) | 4.3 (2.8) a | F(2,36) = 4.53, p < 0.02 |
| MMMSE | 53.2 (16.0) | 53.4 (10.6) | 47.2 (11.0) a | F(2,34) = 14.2, p < 0.0001 |
| TSI | 19.4 (3.2) | 18.6 (3.8) | 18.3 (3.5) a | F(2,32) = 4.49, p < 0.02 |
| VMI | 10.6 (3.7) | 10.1 (3.7) | 9.2 (3.7) a | F(2,38) = 4.59, p < 0.02 |
Abbreviations: ABSI, American Association on Mental Deficiency Adaptive Behavior Scale, Part I; DSMSE, Down Syndrome Mental Status Examination; MCI‐DS, mild cognitive impairment‐Down syndrome; MMMSE, Modified Mini‐Mental Status Examination; MSRT, Modified Selective Reminding Test; TSI, Test for Severe Impairment; VMI, Beery Buktenica Developmental Test of Visual‐Motor Integration.
Indicates a statistically significant change from the previous assessment cycle. Note that only the DSMSE showed a significant decline prior to onset of MCI‐DS.