TABLE 2.
Effects of different G-1 concentrations on breast cancer cell lines.
| G-1 concentration | Experimental cell lines | Results | References |
|---|---|---|---|
| 100 nM | MCF-7, MDA-MB-468, MDA-MB-231, MDA-MB-436 | G-1 activates GPER/ERK signaling which promotes TNBC cell viability and motility | Yu et al. (2014) |
| 1 μM | MDA-MB-231, BT-549, MDA-MB-468, HS578T | G-1 inhibited angiogenesis and migration of TNBC cells | Liang et al. (2017) |
| 1 μM | MDAMB-231, BT-549 | Treatment with G-1 for 24 or 48 h inhibited invasion of TNBC cells | Chen et al. (2016) |
| 10−8–10−5 M | SKBR3, MDA-MB-231 | G-1 inhibited the proliferation of cells in a time-dependent and concentration-dependent manner | Wei et al. (2014) |
| 1 μM | MDA-MB-231, MCF-7, MDA-MB-468, HEK-293 | G-1 inhibited the proliferation of breast cancer cells | Weißenborn et al. (2014) |
| 500 nM, 1 μM, 2 μM | MDA-MB-231, HEK-293 | G-1 suppressed TNBC cell proliferation | Wang et al. (2011) |
| 1–10 nM, 100 nM | SKBR3, MCF-7 | G-1 had no obvious effect on cell proliferation | Lv et al. (2017) |
| MDA-MB-231 | G-1 inhibited breast cancer cell line proliferation | ||
| 1 μM | Breast CAFs | G-1 enhanced CAF proliferation after 72-h culture | Luo et al. (2014) |
| 1 μM | Breast CAFs, SKBR3 | G-1 induced mRNA expression of VEGF. | De Francesco et al. (2014) |
Abbreviations: TNBC, triple-negative breast cancer; ERK, extracellular signal-regulated kinase; CAF, cancer-associated fibroblast; VEGF, vascular endothelial growth factor.