Table 2.
Health status of individuals with Parkinson’s disease, and caregiver burden, by disease severity
| Overall | Early/Int | Advanced | p-value | |
|---|---|---|---|---|
| Physician rating | ||||
| Most recent UPDRS score | 1064 | 936 | 128 | |
| Mean (SD) | 31.9 (27.2) | 29.0 (24.3) | 53.1 (36.2) | < 0.001 |
| Most recent MDS-UPDRS score | 338 | 294 | 44 | |
| Mean (SD) | 33.3 (26.7) | 31.1 (25.3) | 48.4 (31.0) | < 0.001 |
| Most recent MMSE score | 1231 | 968 | 263 | |
| Mean (SD) | 24.4 (4.8) | 25.3 (4.3) | 21.3 (5.3) | < 0.001 |
| Patient rating | ||||
| PDQ-39 | 1869 | 1618 | 251 | |
| Mean (SD) | 27.4 (18.3) | 25.3 (17.3) | 40.9 (18.5) | < 0.001 |
| Caregiver rating | ||||
| Zarit Burden Interview | 853 | 669 | 184 | |
| Mean (SD) | 28.6 (17.7) | 27.2 (17.1) | 33.5 (19.2) | < 0.001 |
| No burden (0–20) | 317 (37.2) | 262 (39.2) | 55 (29.9) | |
| Mild to moderate (21–40) | 305 (35.8) | 250 (37.4) | 55 (29.9) | |
| Moderate to severe (41–60) | 192 (22.5) | 132 (19.7) | 60 (32.6) | |
| Severe (61 +) | 39 ( 4.6) | 25 ( 3.7) | 14 ( 7.6) | |
Int Intermediate, MDS Movement Disorder Society, MMS Mini Mental State Examination, PDQ-39 Parkinson’s Disease Questionnaire (39 items), SD standard deviation, UPDRS Unified Parkinson’s Disease Rating Scale