Despite the simplification of the isotretinoin pregnancy prevention program (PPP) and educational materials in 2018, our study still refers to the ineffectiveness of current efforts.

Although the complete contraceptive coverage during isotretinoin use is slightly improved, it remains still very low and has not resulted in a decrease in the risk of potential isotretinoin-exposed pregnancies.

Differences in contraceptive behavior and risk of potential isotretinoin-exposed pregnancies across age groups suggest that more targeted educational efforts and application of modern assistive technologies are needed to improve the effectiveness of the PPP rather than setting new requirements.