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. 2024 Mar 12;15:2208. doi: 10.1038/s41467-024-46550-y

Fig. 2. Scope of Z-selective hydroboration of terminal alkynes.

Fig. 2

Reaction conditions: terminal alkyne (1.0 equiv, 0.4 mmol), HBpin (1.3 equiv), Co(acac)2 ([Co], 0.5 mol%), CNC-iPr (1.4 equiv to [Co]), tBuOK (5.6 equiv to [Co]) in DMF (0.5 ml) at room temperature (r.t.). See Supplementary Information for experimental details. 1H NMR yields are shown with methylene bromide or mesitylene as the internal standard. Isolated yields and Z/E ratios are provided in parenthesis. a0.1 mmol% Co(acac)2, 0.8 mmol scale. b1 mmol% Co(acac)2. c0.05 mmol% Co(acac)2, yield determined by GC-MS. d24 h. e48 h. f2.5 equiv. HBpin. g3 equiv. HBpin. hWith 10 mol% diphenylacetylene, i0.2 mmol% Co(acac)2. j2 equiv. HBpin.