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. 2024 Mar 11;15:2200. doi: 10.1038/s41467-024-46610-3

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© The Author(s) 2024, corrected publication 2024

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Fig. 3 — a The standard m/z 1 DIA window overlap used in proteomics is insufficient if the goal is to obtain full and intact isotopic envelopes of fragment ions. If any of the isotopologues of the precursor peptide ion are cut out of the DIA bin, the resulting fragment isotopic envelopes will be distorted. b An overlap of m/z 4 was found to be effective for a typical HX-MS experiment with most 2+ and 3+ charged peptides.