TABLE 2.
Assessing predictors of death based on the univariate cox proportional hazards analysis for the disease course duration (time from symptom onset to death)
| Variable | HR | 95% Confidence interval | P‐value | |
|---|---|---|---|---|
| Lower bound | Upper bound | |||
| Gender (M) | 2.08 | 0.71 | 6.15 | 0.18 |
| Age of onset | 1.23 | 0.93 | 1.61 | 0.14 |
| MSA subtype (MSA‐C) | 1.36 | 0.45 | 4.14 | 0.58 |
| Initial symptom (autonomic failure) | 2.89 | 1.04 | 8.05 | 0.04* |
| TST | 0.99 | 0.98 | 1.01 | 0.91 |
| CASS‐A | 1.25 | 0.96 | 1.62 | 0.09* |
| CASS‐T | 1.12 | 0.88 | 1.44 | 0.35 |
| LEDD | 1 | 1 | 1 | 0.29 |
| Dystonia (yes) | 0.52 | 0.18 | 1.52 | 0.52 |
| Babinski (yes) | 1.04 | 0.36 | 3.03 | 1.04 |
| Hyperreflexia (yes) | 1 | 0.36 | 2.78 | 1 |
*
A P‐value <0.10 was considered as statistically significant to move into the multivariate model.
Abbreviations: HR, hazard ratio; M, male; MSA, multiple system atrophy; MSA‐C, multiple system atrophy‐cerebellar ataxia; TST, thermoregulatory sweat test; CASS‐A, Composite Autonomic Severity Score using findings from autonomic reflex screen only; CASS‐T, Composite Autonomic Severity Score using findings from both autonomic reflex screen and thermoregulatory sweat test; LEDD, levodopa equivalent daily dose.