Extended Table 3. 5-ASA use is associated with large-scale differences across individual gut microbial species abundance in patients with IBD.

Significant associations (n=24, FDR q < 0.25) of 5-ASA use and microbial species. All models included each participant’s identifier as random effects and simultaneously adjusted for age, disease type, use of antibiotic, and dysbiosis status.

Species	Beta	P	FDR
Gemmiger formicilis	−0.00518	0.000119	0.007644138
Bifidobacterium longum	0.024185	0.000221	0.009487238
Dielma fastidiosa	0.005456	0.000372	0.011991481
Intestinimonas butyriciproducens	−0.0118	0.000763	0.015567799
Lachnospira pectinoschiza	−0.02995	0.000915	0.015567799
Faecalibacterium prausnitzii	0.077469	0.000987	0.015567799
Fusicatenibacter saccharivorans	−0.02626	0.001075	0.015567799
Phascolarctobacterium faecium	−0.01404	0.001086	0.015567799
Lactobacillus rogosae	−0.00461	0.002316	0.029877308
Eubacterium eligens	0.032305	0.003037	0.035614424
Butyricimonas synergistica	−0.00486	0.003329	0.035790148
Ruminococcus bromii	−0.02084	0.003658	0.036294803
Paraprevotella xylaniphila	−0.00815	0.004008	0.03693114
Turicimonas muris	−0.0055	0.006253	0.053774509
Anaerostipes hadrus	0.021856	0.011292	0.091043147
Ruthenibacterium lactatiformans	−0.01123	0.013849	0.105092694
Parasutterella excrementihominis	−0.0171	0.015598	0.11178451
Anaerotignum lactatifermentans	−0.00775	0.018159	0.123290076
Dialister invisus	−0.01012	0.024624	0.158826559
Anaerotruncus colihominis	−0.00414	0.028712	0.173321541
Bilophila wadsworthia	−0.00699	0.030248	0.173321541
Akkermansia muciniphila	−0.0283	0.03201	0.173321541
Roseburia inulinivorans	−0.0179	0.032246	0.173321541
Proteobacteria bacterium CAG_139	−0.01021	0.045073	0.232574975