Table 1. Disease causing point mutations at analogous phosphoinositide (PIP) binding residues in Naᵥ subtypes (described in the UniProt database).

Naᵥ1.4 residue #	Analogous residue #	Subtype	Disease information; mechanism
K1330	K1505N	Naᵥ1.5	Long QT3 syndrome; unknown significance
R1463	K1641N	Naᵥ1.2	Benign familial infantile seizure; unknown significance
R1469	R1657C	Naᵥ1.1	Generalized epilepsy with febrile seizures plus; depolarizing shift in voltage dependence of activation, reduced current, accelerated recovery from slow inactivation
	R1642C	Naᵥ1.3	Developmental epileptic encephalopathy; accelerated recovery from inactivation
	R1644C R1644H	Naᵥ1.5	Long QT3 syndrome Brugada syndrome