Table 2.
Median Age (Years) and Interquartile Range at Various Diagnostic Steps for Males Born Full-Term and Preterm With Duchenne Muscular Dystrophy, MD STARnet, 1982-2011.
| Full-term males (n = 356) | Preterm males (n = 43) | |||||||
|---|---|---|---|---|---|---|---|---|
| n (%) | Median age, y (IQR) |
Min, Max, y | n (%) | Median age, y (IQR) |
Min, Max, y |
P valuea |
P valueb |
|
| Age at loss of ambulation | 225 (63.2) | 10.4 (3.1) | 6.7, 15.9 | 28 (65.1) | 9.9 (2.9) | 5.5, 15.8 | .87 | .28 |
| Age at assisted ventilation | ||||||||
| Noninvasive ventilation | 94 (26.4) | 15.7 (3.6) | 6.5, 22.4 | 10 (23.3) | 16.3 (6.3) | 8.9, 18.6 | .72 | .73c |
| Cough machine | 72 (20.2) | 18.1 (4.8) | 8.8, 25.5 | 8 (18.6) | 13.9 (4.9) | 10.0, 18.6 | >.99 | .05 c |
| Tracheostomy | 23 (6.5) | 17.5 (3.4) | 12.7, 25.9 | 3 (6.9) | 19.5 (1.6) | 18.9, 20.6 | .75 | 0.42c,d |
| Any intervention | 113(31.7) | 15.5 (4.4) | 6.5, 24.2 | 13 (30.2) | 14.3 (6.7) | 8.9, 18.6 | >.99 | .22c |
| Age at onset of LVD | 114 (32.0) | 14.5 (5.1) | 2.4, 21.3 | 11 (25.6) | 15.0 (8.7) | 5.5, 18.1 | .49 | .98 |
| Age at first corticosteroid use | 221 (62.1) | 6.6 (2.6) | 2.7, 14.2 | 25 (58.1) | 6.5 (3.0) | 4.3, 14.7 | .62 | .67 |
| Age at last clinical visit | 356 (100) | 13.9 (9.3) | 1.9, 27.9 | 43 (100) | 11.74 (8.2) | 2.3, 22.9 | – | .12 |
| Age at diagnosis | 356 (100) | 4.6 (3.2) | 0, 15.1 | 43 (100) | 3.8 (3.2) | 0, 10.7 | – | .11 |
Abbreviations: IQR, interquartile range; LVD, left ventricular dysfunction; Max, maximum age; Min, minimum age; MD STARnet, Muscular Dystrophy Surveillance, Tracking, and Research Network.
a
Fisher exact test of independence.
b
Wilcoxon rank-sum test.
c
Holm-Bonferroni correction.
d
Wilcoxon rank-sum exact test.