Table 4. Classification and management of ICI related encephalitis.

Severity	Representation	Management
G1	Mild symptoms not limiting daily life	ICI treatment be maintained and the diagnostic process started. If there is no improvement or symptom deterioration, ICIs should be stopped permanently
G2	New moderate or severe neurological signs or symptoms	ICI treatment can be maintained temporarily, but symptoms and signs should be closely monitored. Antiviral drugs or antibiotics may empirically use as prevention
G3–G4	Severe limitations in daily life activities or life threatening or encephalitis with psycho-behavioral abnormalities	ICIs should be permanently stopped, and high-dose glucocorticoids (0.5–1 mg/kg/d) should be given if there is no infection

ICI, immune checkpoint inhibitor.