Table 2.
Association of known SLE-assciated loci with varied subphenotypes in the Thai dataset
| SNP | Gene | Allele A* | Arthritis | Haematological disorder | Neurological disorder | Rash | Renal disorders | Serological disorder | Ulcer | |||||||
| OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | |||
| rs13397 | TMEM187 | G | 1.04 0.92 to 1.17 |
0.73 | 1.09 0.97 to 1.22 |
0.46 | 1.21 1.02 to 1.41 |
0.31 | 0.94 0.82 to 1.06 |
0.62 | 1.12 1.00 to 1.24 |
0.36 | 1.05 0.92 to 1.18 |
0.7 | 1.26 1.11 to 1.42 |
0.12 |
| rs3853839 | TLR7 | G | 1.05 0.91 to 1.19 |
0.73 | 0.9 0.77 to 1.03 |
0.42 | 0.97 0.76 to 1.18 |
0.88 | 1.02 0.88 to 1.15 |
0.91 | 0.97 0.84 to 1.10 |
0.82 | 1.01 0.87 to 1.15 |
0.95 | 0.99 0.82 to 1.15 |
0.94 |
| rs7059565 | PRPS2 | T | 1.01 0.88 to 1.13 |
0.95 | 0.99 0.87 to 1.12 |
0.95 | 0.8 0.61 to 0.99 |
0.25 | 0.9 0.78 to 1.02 |
0.38 | 1.05 0.92 to 1.17 |
0.71 | 1.24 1.10 to 1.37 |
0.1 | 1.10 0.95 to 1.26 |
0.51 |
| rs12011862 | GPR173 | G | 1.15 1.02 to 1.29 |
0.30 | 1.14 1.01 to 1.27 |
0.32 | 0.78 0.58 to 0.99 |
0.24 | 1.17 1.04 to 1.30 |
0.23 | 0.99 0.86 to 1.11 |
0.91 | 1.00 0.86 to 1.14 |
0.99 | 0.84 0.68 to 1.00 |
0.29 |
*OR is with respect to allele A (allele A would be the risk allele when OR >1).
SNP, single-nucleotide polymorphism.