Table 4.
Cox regression analysis for prediction of OS in 122 patients with high tumor burden
| Variables | Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| HR (95% Cl) | p value | HR (95% Cl) | p value | |
| Age, 1 year increase | 1.01 (0.99–1.03) | 0.265 | 1.01 (0.99–1.03) | 0.259 |
| Male (vs. female) | 0.86 (0.48–1.55) | 0.624 | 1.04 (0.57–1.90) | 0.891 |
| FIB-4 index, 1 point increase | 1.13 (1.05–1.21) | 0.005 | 1.06 (0.97–1.16) | 0.190 |
| ALBI score, 1 point increase | 1.67 (1.15–2.44) | 0.007 | 1.28 (0.80–2.04) | 0.299 |
| AFP, 1 ng/mL increase | 1.00 (1.00–1.00) | 0.422 | ||
| HBV positive (vs. negative) | 1.28 (0.80–2.05) | 0.296 | ||
| HCV positive (vs. negative) | 1.72 (0.98–3.03) | 0.058 | ||
| Cirrhosis (vs. no) | 1.00 (0.62–1.59) | 0.965 | ||
| SR versus TACE | 0.46 (0.28–0.75) | 0.002 | 0.54 (0.32–0.92) | 0.022 |
OS, overall survival; HR, hazard ratio; Cl, confidence interval; FIB-4 index, fibrosis-4 index; ALBI score, albumin-bilirubin score; AFP, a-fetoprotein; HBV, hepatitis B virus; HCV, hepatitis C virus; SR, surgical resection; TACE, transarterial chemoembolization.