Table 6.

Cox regression analysis for prediction of OS in 229 patients with multinodular HCCs

Variables	Univariable analysis		Multivariable analysis
	HR (95% Cl)	p value	HR (95% Cl)	p value
Age, 1 year increase	1.01 (0.99–1.03)	0.281	1.02 (1.00–1.04)	0.021
Male (vs. female)	0.78 (0.51–1.17)	0.232	0.91 (0.60–1.38)	0.645
FIB-4 index, 1 point increase	1.02 (0.98–1.06)	0.382
ALBl score, 1 point increase	1.56 (1.16–2.11)	0.004	1.57 (1.13–2.17)	0.007
AFP, 1 ng/mL increase	1.00 (1.00–1.00)	<0.001	1.00 (1.00–1.00)	<0.001
HBV positive (vs. negative)	1.05 (0.73–1.52)	0.792
HCV positive (vs. negative)	0.89 (0.60–1.31)	0.546
Cirrhosis (vs. no)	0.78 (0.52–1.18)	0.236
Seven-eleven criteria
Low tumor burden	1		1
Intermediate tumor burden	1.58 (0.98–2.53)	0.493	1.44 (0.88–2.33)	0.143
High tumor burden	2.95 (1.83–4.75)	<0.001	2.95 (1.79–4.85)	<0.001
SR versus TACE	0.55 (0.35–0.86)	0.009	0.57 (0.35–0.93)	0.024

OS, overall survival; HCC, hepatocellular carcinoma; HR, hazard ratio; Cl, confidence interval; FlB-4 index, fibrosis-4 index; ALBl score, albumin-bilirubin score; AFP, a-fetoprotein; HBV, hepatitis B virus; HCV, hepatitis C virus; SR, surgical resection; TACE, transarterial chemoembolization.