In vitro cytotoxic activity values and corresponding therapeutic index of 12a, 12b, and doxorubicin against the two human cancer cell lines (lung (A549) and colon (Caco-2)) and the normal lung (WI-38) cell line.
| Compounds | IC50 (μg mL−1) | Therapeutic index (TI) | |||
|---|---|---|---|---|---|
| Lung cancer (A549) | Colon cancer (Caco-2) | Normal lung (WI-38) | Lung cancer (A549) | Colon cancer (Caco-2) | |
| 12a | 47.83 | 38.15 | 134.24 | 2.8 | 3.5 |
| 12b | 40.54 | 29.77 | 304.88 | 7.52 | 10.24 |
| Doxorubicin | 31.32 | 28.45 | 75.98 | 2.42 | 2.67 |