Toxicity endpoint properties and the median lethal dose (LD50) of the two pyrazolo[1,5-a]pyrimidines 12a and 12b.
| Parameter | 12a | 12b |
|---|---|---|
| Toxicity endpoint properties | ||
| Carcinogenicity | Active | Inactive |
| Cytotoxicity | Inactive | Inactive |
| Mutagenicity | Active | Inactive |
| Immunotoxicity | Inactive | Inactive |
| Median lethal dose (LD 50 , mg kg− 1 ) | ||
| Predicted LD50 | 1000 | 1000 |
| Predicted toxicity class | 4 | 4 |