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. 2024 Mar 12;14(12):8397–8408. doi: 10.1039/d4ra00423j

Toxicity endpoint properties and the median lethal dose (LD50) of the two pyrazolo[1,5-a]pyrimidines 12a and 12b.

Parameter 12a 12b
Toxicity endpoint properties
Carcinogenicity Active Inactive
Cytotoxicity Inactive Inactive
Mutagenicity Active Inactive
Immunotoxicity Inactive Inactive
Median lethal dose (LD 50 , mg kg 1 )
Predicted LD50 1000 1000
Predicted toxicity class 4 4