Figure 3.

Antibiotic administration exacerbates inflammation and upregulates IgE expression in the asthma mouse model. (A) H&E staining of the lung sections of mice in different groups. Blue arrow, alveolar wall thickening; green arrow, neutrophils; black arrow, bronchial epithelial cells that are shed; (B) H&E staining of the colon sections of mice in different groups. Green arrow, lymphocytic infiltration; red arrow, granulocyte infiltration; black arrow, mucosal epithelial cells of intestinal tissue that are shed. (C) The levels of TGF-β in the lung tissue homogenate of mice in different groups. (D) The expression of OVA-induced IgE in the serum of mice in different groups (n=5). ^*P<0.05 and ^**P<0.01, control group vs. model group; ^##P<0.01 control 2 group vs. control group; ^P<0.05 and ^{^^}P<0.01, model group vs. OVA-ABX and ABX-OVA group; ^∆P<0.05 and ^∆∆P<0.01, model 2 group vs. OVA-ABX 2 and ABX-OVA 2 group. IgE, immunoglobulin E; H&E, Hematoxylin and eosin OVA, ovalbumin; ABX, antibiotics.