Table 2.
Longitudinal Assessment of Cardiopulmonary Function in Lung Cancer Patients Undergoing Radiotherapy
| Body Composition & Physical Activity | |||
| Baseline | Follow-up | P -value | |
| Body mass index, kg/m2 | 30.2 [24.4–35.1] | 30.2 [23.4–35.2] | 0.878 |
| Physical Activity, MET/Min/week | 1152 [122–1841] | 759 [282–2804] | 0.333 |
| Health-related Quality of Life | |||
| FACT-G7 | 21.5 [18.8–25.0] | 15.5 [11.5–20.0] | 0.021 |
| Lab Values | |||
| Hemoglobin, g/dL | 12.7 [11.4–14.3] | 12.6 [11.5–13.4] | 0.102 |
| hsCRP, mg/L | 4.4 [1.4–5.8] | 6.1 [3.7–20.7] | 0.047 |
| NT-proBNP, pg/mL | 65 [49–125] | 121 [88–191] | 0.110 |
| Pulmonary Function | |||
| FVC, % | 84 [62–98] | 84 [66–98] | 0.959 |
| FEV-1, % | 75 [60–102] | 79 [65–102] | 0.575 |
| FEV-1/FVC ratio | 0.71 [0.64–0.85] | 0.75 [0.70–0.83] | 0.553 |
| DLCO-corrected, % | 62 [51–80] | 60 [59–67] | 0.779 |
| Cardiopulmonary Exercise Test Variables | |||
| VO2peak, L·min− 1 | 1.245 [0.882–1.605] | 1.095 [0.810–1.448] | 0.047 |
| VO2peak, %-predicted | 70 [62–86] | 62 [56–76] | 0.005 |
| VO2peak, mL·kg− 1·min− 1 | 13.8 [11.9–20.3] | 13.5 [10.6–18.0] | 0.047 |
| VE/VCO2 slope | 31.0 [27.5–35.1] | 32.7 [29.1–38.9] | 0.139 |
| OUES | 1.63 [1.27–1.88] | 1.57 [1.12–1.75] | 0.032 |
| Peak RER | 1.11 [1.04–1.14] | 1.12 [1.04–1.20] | 0.241 |
| Breathing reserve, % | 61 [51–85] | 65 [49–73] | 0.515 |
| Exercise time, sec | 418 [355–707] | 405 [331–643] | 0.169 |
| Resting heart rate, bpm | 82 [63–84] | 83 [70–92] | 0.838 |
| Peak heart rate, bpm | 127 [119–148] | 124 [118–134] | 0.241 |
| Resting systolic blood pressure, mmHg | 139 [126–149] | 122 [111–133] | 0.109 |
| Resting diastolic blood pressure, mmHg | 81 [76–83] | 78 [70–83] | 0.539 |
| Peak systolic blood pressure, mmHg | 176 [152–198] | 163 [138–191] | 0.114 |
| Peak diastolic blood pressure, mmHg | 78 [74–86] | 71 [70–76] | 0.008 |
| Rest Echo Parameters | |||
| Left-ventricular ejection fraction, % | 62 [56–65] | 66 [57–68] | 0.475 |
| Left-atrial volume index, mL/m2 | 26.9 [18.6–33.3] | 24.3 [18.7–27.2] | 0.646 |
| E, cm/sec | 71 [62–86] | 72 [53–84] | 0.285 |
| A, cm/sec | 81 [68–97] | 86 [73–101] | 0.093 |
| E/A ratio | 0.83 [0.69–1.11] | 0.78 [0.66–0.96] | 0.114 |
| Septal e’, cm/sec | 6.5 [5.5–8.2] | 8.7 [7.7–11.1] | 0.028 |
| Lateral e’, cm/sec | 9.8 [7.5–11.4] | 11.2 [7.5–11.6] | 0.646 |
| Average e’, cm/sec | 8.4 [6.5-9.0] | 9.5 [7.5–10.7] | 0.203 |
| E/e’ | 7.9 [7.3–12.8] | 7.5 [6.6–9.9] | 0.169 |
| Stress Echo Parameters | |||
| E, cm/sec | 105 [87–127] | 104 [74–116] | 0.508 |
| Septal e’, cm/sec | 11.0 [9.5–13.3] | 10.4 [8.6–12.3] | 0.173 |
| Lateral e’, cm/sec | 13.1 [11.9–17.0] | 11.8 [8.6–15.1] | 0.139 |
| Average e’, cm/sec | 12.9 [11.0-13.7] | 11.3 [8.5–13.4] | 0.126 |
| Δstress e’, cm/sec | 4.5 [3.4–5.2] | 1.3 [0.3–4.5] | 0.022 |
| E/e’ | 8.3 [5.5–10.7] | 8.4 [7.1–11.3] | 0.386 |
| DFRI (e’ x Δstress e’) | 34.9 [22.7–41.6] | 12.8 [3.1–35.9] | 0.037 |
Data are listed as median [IQR] or number (%). Bold values = P < 0.05 for comparison between baseline and follow-up visit
Abbreviations: Δ = delta; A = late transmitral velocity; DFRI = diastolic functional reserve index; DLCO = diffusion capacity of carbon monoxide; E = early transmitral velocity; e’= early diastolic mitral annular velocity; FACT-G7 = functional assessment of cancer therapy-general-7; FEV-1 = forced expiratory volume at 1-second; FVC = forced vital capacity; hsCRP = high-sensitivity C-reactive protein; MET = metabolic equivalent of task; NT-proBNP = N-terminal pro-brain natriuretic peptide; OUES = oxygen uptake efficiency slope; RER = respiratory exchange ratio; VE/VCO2 = minute ventilation to carbon dioxide production; VO2 = oxygen consumption