Table 2.
Adverse drug reactions and implicated antibiotics
| Adverse Drug Reactions | Tolerant | Intolerant |
|---|---|---|
| Common Terminology Criteria for Adverse Events Grade 3 or greater1 (Total) |
3 (2%) | 13 (13%) |
| Gastrointestinal symptoms | 34 (23%) | 58 (55%) |
| Rash | 4 (3%) | 9 (8.5%) |
| Fatigue | 5 (3%) | 23 (22%) |
| Cough, dysphonia, or bronchospasm | 4 (3%) | 4 (4.7%) |
| Visual disturbance | 2 (1%) | 11 (10%) |
| Auditory disturbance | 1 (0.7%) | 5 (5%) |
| Acute kidney injury | 0 | 4 (4%) |
| Hemoptysis | 0 | 1 (1%) |
| Anaphylaxis | 0 | 1 (1%) |
| Other | 6 (4%) | 8 (8%) |
| Implicated Antibiotic | ||
| Macrolides | 12 (8%) | 21 (19%) |
| Rifamycins | 4 (3%) | 46 (43%) |
| Ethambutol | 3 (2%) | 22 (20%) |
| Amikacin liposomal inhalation suspension | 4 (3%) | 11 (10%) |
| Parenteral Amikacin | 0 | 5 (5%) |
1: Common Terminology Criteria for Adverse Events [CTCAE] Grade 3 is defined as severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care