Table 4.
Subgroup analysis
| Osteoarthritis | ||
|---|---|---|
| OR (95% CI), p value | P for interaction | |
| Stratified by gender | 0.4823 | |
| Male | 1.28 (0.95, 1.71) 0.0989 | |
| Female | 1.46 (1.13, 1.88) 0.0036 | |
| Stratified by age | 0.2983 | |
| Age < 65 | 1.47 (1.16, 1.87) 0.0015 | |
| Age ≥ 65 | 1.21 (0.89, 1.65) 0.2287 | |
| Stratified by BMI | 0.0923 | |
| Normal (BMI < 25 kg/m2) | 2.12 (1.28, 3.52) 0.0037 | |
| Overweight (25 ≤ BMI ˂30 kg/m2) | 1.38 (0.99, 1.92) 0.0574 | |
| Obese (BMI ≥ 30 kg/m2) | 1.24 (0.94, 1.64) 0.1330 | |
| Stratified by smoking | 0.8307 | |
| Yes | 1.34 (1.04, 1.72) 0.0258 | |
| No | 1.38 (1.08, 1.77) 0.0113 | |
| Stratified by diabetes | 0.0465 | |
| Yes | 1.02 (0.69, 1.51) 0.9112 | |
| No | 1.63 (1.28, 2.08) < 0.0001 | |
Model 1 was adjusted for no covariates;
Model 2 was adjusted for age, gender, and race;
Model 3 was adjusted for all covariates except effect modifier
OR, odds ratio; 95% CI, 95% confidence interval