Table 2.
Univariate MR estimates between common risk factors and irAEs
| Exposures | Method | NSNP | Outcomes | |||
|---|---|---|---|---|---|---|
| High-grade irAEs | All-grade irAEs | |||||
| Beta (95%CI) | p value | Beta (95%CI) | p value | |||
| Anthropometric factors | ||||||
| BMI | IVW | 314 | − 0.60 (− 1.34, 0.14) | 0.11 | − 0.74 (− 1.41, − 0.06) | 0.03 |
| Waist circumference | IVW | 26 | 0.61 (− 1.01, 2.23) | 0.46 | 0.05 (− 1.15, 1.24) | 0.94 |
| Waist circumference (adjusted for BMI) | IVW | 46 | 0.00 (− 1.37, 1.38) | 1.00 | − 0.39 (− 1.5, 0.73) | 0.50 |
| Hip circumference | IVW | 38 | 0.09 (− 0.92, 1.10) | 0.86 | − 0.63 (− 1.7, 0.44) | 0.25 |
| Hip circumference (adjusted for BMI) | IVW | 52 | 0.65 (− 0.38, 1.69) | 0.21 | 0.47 (− 0.52, 1.45) | 0.35 |
| Waist-to-hip ratio | IVW | 20 | − 0.28 (− 2.21, 1.64) | 0.77 | − 1.69 (− 3.56, 0.18) | 0.08 |
| Waist-to-hip ratio (adjusted for BMI) | IVW | 25 | 0.84 (− 0.88, 2.55) | 0.34 | − 0.54 (− 1.94, 0.85) | 0.44 |
| Lifestyle factors | ||||||
| Alcoholic drinks per week | IVW | 14 | − 0.44 (− 4.21, 3.33) | 0.82 | − 0.06 (− 3.24, 3.12) | 0.97 |
| Cigarettes smoked per day | IVW | 13 | 0.11 (− 0.93, 1.16) | 0.83 | 0.67 (− 0.29, 1.63) | 0.17 |
| Smoking initiation | IVW | 54 | 0.08 (− 1.21, 1.37) | 0.90 | − 0.10 (− 1.23, 1.04) | 0.87 |
| Type 2 diabetes | IVW | 79 | − 0.16 (− 0.48, 0.17) | 0.34 | 0.01 (− 0.33, 0.34) | 0.97 |
BMI body mass index, IVW Inverse variance weighted method, NSNP number of SNPs, irAEs immune-related adverse events, 95% CI 95% confidential interval, High-grade irAEs, grade 3–5 irAEs