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. 2024 Feb 11;20(5):1602–1616. doi: 10.7150/ijbs.85526

Figure 7.

Figure 7

PARP1 improves cardiac repair and cardiomyocyte proliferation in adult mice after MI. Representative western blot images and statistical analysis of PARP1 protein expression in C57BL/6J WT mice heart intramyocardially injected with AAV9-Ctrl and AAV9-PARP1. GAPDH was used as a loading control (n=6 per group). *P< 0.05 by unpaired Student's t-test. (B and C) Masson staining images and statistical analysis of scar size in AAV9-Ctrl and AAV9-PARP1 mice post MI (n=5-6 per group). Scale bars, 1mm. ***P< 0.001 by unpaired Student's t-test. (D and E) Representative images and statistical analysis of EF and FS of echocardiography post-MI and 28 dpi in AAV9-Ctrl and AAV9-PARP1 mice (n=10 per group). **P< 0.01 by unpaired Student's t-test. (F and G) Representative immunostaining images and statistical analysis of BrdU+ and Ki67+ (white) cardiomyocytes in AAV9-Ctrl mice and AAV9-PARP1 mice at 28dpi (n=5-7 per group). Scale bars, 10μm. **P< 0.01 by ANOVA followed by the Bonferroni test.