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. 2024 Feb 12;20(5):1669–1687. doi: 10.7150/ijbs.90872

Figure 2.

Figure 2

CDK12 is downregulated in cisplatin- and IR-induced AKI murine models. (A) Representative micrographs show kidney morphology in wild-type (WT) mice and mice with cisplatin- and I/R-induced AKI. Images of PAS staining are shown (scale bar =50 μm). At least 20 randomly selected fields were evaluated under ×400 magnification and results were averaged for each kidney (n=5). (B) Scr and BUN levels in the four groups, as indicated. Scr was expressed as micromoles per liter, and BUN was expressed as millimoles per liter. *P<0.05 versus WT (n=5) (C) Representative micrographs show CDK12 localized in LTL+ proximal tubules. Sequential paraffin-embedded kidney sections in four groups were immunostained for CDK12 and LTL. Boxed areas are enlarged and indicate tubules of mice with AKI lack CDK12 nuclear expression (scale bar = 50 μm). (D) Representative western blots showing the renal expression of CDK12 in four group. Graphical representations of CDK12 expression levels in four groups, as indicated. *P<0.05 versus WT (n=5). WT, wild type; CP, cisplatin; Scr, serum creatinine; BUN, urea nitrogen.