Table 1.
Demographic and medical variables
| N (%) or mean (SD) | Overall (N = 66) | No PTSS (N = 43) | PTSS (N = 23) | P-value1 |
|---|---|---|---|---|
| Female sex | 23 (35) | 15 (35) | 8 (35) | >0.99 |
| Age at assessment (years) | 12.53 (2.81) | 12.04 (2.83) | 13.40 (2.62) | 0.06 |
| Time since diagnosis (days) | 393 (76) | 390 (86) | 400 (52) | 0.57 |
| NPS score | 4.11 (2.11) | 4.00 (2.06) | 4.30 (2.22) | 0.59 |
| Tumor location | ||||
| Cerebral lobes | 12 (18) | 10 (23) | 2 (9) | |
| Supratentorial medial structures | 22 (33) | 15 (35) | 7 (30) | |
| Posterior fossa | 32 (48) | 18 (42) | 14 (61) | |
| Tumor type | ||||
| Low-grade glioma | 31 (47) | 21 (49) | 10 (43) | |
| High-grade glioma | 2 (3) | 1 (2) | 1 (4) | |
| Medulloblastoma | 7 (11) | 4 (9) | 3 (13) | |
| Ependymoma | 2 (3) | 1 (2) | 1 (4) | |
| Germ cell tumor | 10 (15) | 7 (16) | 3 (13) | |
| Craniopharyngioma | 10 (15) | 7 (16) | 3 (13) | |
| Other2 | 4 (6) | 2 (5) | 2 (9) | |
| Neurosurgery | ||||
| No | 8 (12) | 6 (14) | 2 (9) | |
| Biopsy only | 5 (8) | 4 (9) | 1 (4) | |
| One resection | 48 (73) | 31 (72) | 17 (74) | |
| Several resections | 5 (8) | 2 (5) | 3 (13) | |
| Radiotherapy | ||||
| No radiotherapy | 43 (65) | 31 (72) | 12 (52) | |
| Focal radiotherapy | 11 (17) | 5 (12) | 6 (26) | |
| Whole brain or craniospinal | 4 (6) | 2 (5) | 2 (9) | |
| Whole brain + boost | 8 (12) | 5 (12) | 3 (13) | |
| Radiotherapy type | ||||
| Photon | 7 (11) | 2 (5) | 5 (22) | |
| Proton | 16 (24) | 10 (23) | 6 (26) | |
| Chemotherapy | 18 (27) | 11 (26) | 7 (30) | |
| Cerebellar mutism syndrome | 5 (8) | 2 (5) | 3 (13) | |
| Metastases at diagnosis | 9 (14) | 7 (16) | 2 (9) | |
| Hormone deficiency | 20 (31) | 15 (35) | 5 (23) | |
| Epilepsy with seizure medication | 7 (11) | 6 (14) | 1 (4) | |
| Obstructive hydrocephalus | 30 (45) | 19 (44) | 11 (48) | |
| Total Motion Index (MRI) | 1.10 (2.06) | 1.28 (2.16) | 0.75 (1.85) | 0.35 |
1Independent t-tests between no PTSS and PTSS group. t-Tests were only performed on variables that influenced the sample selection.
2Choroid plexus tumor, atypical teratoid rhabdoid tumor, mesenchyoma, and meningioma.