Table 4.
Multivariable regression models of FA and AD of the 8 white matter tracts
| B (95%CI) | Fractional anisotropy (N = 52) | |||
|---|---|---|---|---|
| Anterior commissure | Anterior thalamic radiation | Cingulum bundle dorsal | Cingulum bundle ventral | |
| (Intercept) | 0.28 (0.23 to 0.34)*** | 0.30 (0.23 to 0.36)*** | 0.35 (0.27 to 0.43)*** | 0.34 (0.23 to 0.45)*** |
| PTSS group Yes vs. no |
0.01 (−0.02 to 0.04) | −0.00 (−0.04 to 0.03) | 0.03 (−0.00 to 0.07) | 0.00 (−0.05 to 0.06) |
| Age at diagnosis Continuous |
0.00 (−0.00 to 0.00) | 0.01 (0.00 to 0.01)* | −0.01 (−0.01 to 0.00) | −0.00 (−0.01 to 0.01) |
| NPS score Continuous |
0.00 (−0.00 to 0.01) | −0.01 (−0.01 to −0.00)* | 0.01 (0.00 to 0.02)** | 0.01 (−0.00 to 0.02) |
| Tumor location Suprat. vs. rest |
−0.03 (−0.05 to 0.00) | −0.02 (−0.05 to 0.01) | −0.01 (−0.05 to 0.02) | −0.01 (−0.06 to 0.04) |
| Corticospinal tract | Fornix | Uncinate fasciculus | Middle cerebellar peduncle | |
|---|---|---|---|---|
| (Intercept) | 0.49 (0.43 to 0.55)*** | 0.37 (0.31 to 0.42)*** | 0.31 (0.26 to 0.36)*** | 0.42 (0.36 to 0.48)*** |
| PTSS group Yes vs. no |
0.00 (−0.02 to 0.03) | −0.01 (−0.03 to 0.02) | 0.01 (−0.02 to 0.03) | 0.02 (−0.01 to 0.04) |
| Age at diagnosis Continuous |
0.01 (0.00 to 0.01)* | 0.00 (−0.00 to 0.01) | 0.00 (−0.00 to 0.01) | 0.00 (−0.00 to 0.01) |
| NPS score Continuous |
0.00 (−0.00 to 0.01) | −0.00 (−0.01 to 0.00) | 0.00 (−0.01 to 0.01) | 0.00 (−0.00 to 0.01) |
| Tumor location Suprat. vs. rest |
−0.01 (−0.04 to 0.02) | −0.04 (−0.06 to −0.01)** | −0.03 (−0.05 to −0.00)* | 0.01 (−0.02 to 0.04) |
| Axial diffusivity (N = 52) | ||||
|---|---|---|---|---|
| Anterior commissure | Anterior thalamic radiation | Cingulum bundle dorsal | Cingulum bundle ventral | |
| (Intercept) | 0.88 (0.82 to 0.94)*** | 0.88 (0.84 to 0.93)*** | 0.87 (0.75 to 0.99)*** | 0.92 (0.84 to 1.00)*** |
| PTSS group Yes vs. no |
0.00 (−0.02 to 0.03) | 0.00 (−0.02 to 0.03) | 0.02 (−0.04 to 0.07) | 0.02 (−0.02 to 0.06) |
| Age at diagnosis Continuous |
−0.01 (−0.01 to −0.00)** | −0.00 (−0.01 to −0.00)* | −0.01 (−0.02 to 0.00) | −0.01 (−0.01 to −0.00)* |
| NPS score Continuous |
0.00 (−0.00 to 0.01) | 0.00 (−0.00 to 0.01) | 0.01 (−0.00 to 0.03) | 0.00 (−0.01 to 0.01) |
| Tumor location Suprat. vs. rest |
−0.01 (−0.04 to 0.02) | −0.01 (−0.03 to 0.01) | 0.05 (−0.00 to 0.11) | −0.01 (−0.04 to 0.03) |
| Corticospinal tract | Fornix | Uncinate Fasciculus | Middle Cerebellar Peduncle | |
|---|---|---|---|---|
| (Intercept) | 0.87 (0.79 to 0.94)*** | 0.99 (0.94 to 1.05)*** | 0.90(0.84 to 0.97)*** | 0.80 (0.74 to 0.86)*** |
| PTSS group Yes vs. no |
0.01 (−0.03 to 0.04) | 0.00 (−0.02 to 0.03) | 0.02 (−0.01 to 0.05) | 0.00 (−0.02 to 0.03) |
| Age at diagnosis Continuous |
−0.00 (−0.01 to 0.00) | −0.00 (−0.01 to −0.00)* | −0.00 (−0.01 to 0.00) | −0.00 (−0.01 to 0.00) |
| NPS score Continuous |
0.00 (−0.01 to 0.01) | 0.00 (−0.01 to 0.01) | 0.00 (−0.01 to 0.01) | 0.00 (−0.00 to 0.01) |
| Tumor location Suprat. vs. rest |
−0.01 (−0.05 to 0.02) | −0.01 (−0.04 to 0.01) | −0.03 (−0.06 to −0.00)* | −0.04 (−0.07 to −0.01)** |
Abbreviations. Suprat. = supratentorial medial structures.
* Significant at the P < .05 level.
** Significant at the P < .01 level.
*** Significant at the P < .001 level.