Fig. 4. National and international authorities, agencies and initiatives developing frameworks, legislations, and guidelines for nanomaterials. UN, United Nations; WHO, World Health Organisation; UNEP, United Nations Environment Program; UNITAR, United Nations Institute for Training and Research; OECD, Organisation for Economic Cooperation and Development; WPMN, Working Party on Manufactured Nanomaterials; ISO, International Organisation for Standardisation; ISO-TC229, International Organisation for Standardisation Technical Committee 229; USA, United States of America; FDA, Food and Drug Administration; EPA, Environmental Protection Agency; SINANOTOX, National Nanotoxicological Evaluation System Initiative; CONAHCyT, National Council of Humanities, Sciences and Technologies; CENAM, National Centre of Metrology; CENAT, National Centre of High Technology; LANOTEC, National Laboratory of Nanotechnology; ICONTEC, Colombian Institute of Technical Norms; ABNT, Brazilian Association of Technical Norms; IRAM, Argentinian Institute of Normalisation and Certification; REACH, Registration, Evaluation, Authorisation, and Restriction Chemicals; ECHA, European Chemical Agency; EUON, European Union Observatory for Nanomaterials. Original creation (using Excel and Biorender programs) based on information obtained from ref. 12, 31, 79–81, 94, 98, 115, 124–137, 143, 144_,159, 180, 189, 202–204, 269.