Table 2.
Dementia risk associated with a 1-SD difference in hemostatic factor levels in 1992/1993 among eligible CHS Cognition Study participants (followed from 1992/1993–1998/1999).
| Minimally-Adjusted | Fully-Adjusted | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Model 1a | Model 2b | |||||||
|
| ||||||||
| SD | Person-Years | n Dementia | Rate/1000-Person-Years | HR | 95% CI | HR | 95% CI | |
|
| ||||||||
| Any Dementia | ||||||||
| Fibrinogen, mg/dL | 62.8 | 17,199 | 446 | 25.9 | 1.05 | (0.95, 1.15) | 1.05 | (0.95, 1.16) |
| FVIIc, % | 23.3 | 17,024 | 440 | 25.8 | 1.01 | (0.91, 1.12) | 1.03 | (0.92, 1.16) |
| FVIIa, mU mL−1 | 23.1 | 12,920 | 322 | 24.9 | 1.04 | (0.93, 1.17) | 1.03 | (0.91, 1.16) |
| FVIIa-AT, pM | 46.7 | 13,029 | 327 | 25.1 | 1.11 | (0.99, 1.24) | 1.10 | (0.98, 1.24) |
| FXI antigen, % | 30.3 | 16,699 | 428 | 25.6 | 1.03 | (0.94, 1.14) | 1.01 | (0.92, 1.12) |
| Peak thrombin generation, nM | 131.9 | 16,071 | 400 | 24.9 | 1.00 | (0.90, 1.11) | 1.05 | (0.94, 1.18) |
| Platelet count, ×109 L−1 | 63.4 | 16,998 | 439 | 25.8 | 1.01 | (0.92, 1.12) | 1.02 | (0.93, 1.13) |
| Alzheimer’s Disease | ||||||||
| Fibrinogen, mg/dL | 62.8 | 17,199 | 233 | 13.5 | 1.09 | (0.95, 1.24) | 1.14 | (0.99, 1.30) |
| FVIIc, % | 23.3 | 17,024 | 231 | 13.6 | 1.00 | (0.86, 1.15) | 1.03 | (0.88, 1.20) |
| FVIIa, mU mL−1 | 23.1 | 12,920 | 170 | 13.2 | 0.99 | (0.85, 1.16) | 0.98 | (0.83, 1.16) |
| FVIIa-AT, pM | 46.7 | 13,029 | 172 | 13.2 | 1.17 | (1.01, 1.36) | 1.18 | (1.01, 1.38) |
| FXI antigen, % | 30.3 | 16,699 | 223 | 13.4 | 1.07 | (0.93, 1.23) | 1.05 | (0.91, 1.21) |
| Peak thrombin generation, nM | 131.9 | 16,070 | 206 | 12.8 | 0.92 | (0.80, 1.07) | 0.97 | (0.83, 1.13) |
| Platelet count, ×109 L−1 | 63.4 | 16,998 | 229 | 13.5 | 1.09 | (0.95, 1.24) | 1.12 | (0.98, 1.27) |
| Vascular Dementia | ||||||||
| Fibrinogen, mg/dL | 62.8 | 17,199 | 52 | 3.0 | 1.04 | (0.79, 1.37) | 0.92 | (0.69, 1.22) |
| FVIIc, % | 23.3 | 17,024 | 53 | 3.1 | 0.96 | (0.70, 1.30) | 0.82 | (0.58, 1.17) |
| FVIIa, mU mL−1 | 23.1 | 12,920 | 35 | 2.7 | 1.11 | (0.79, 1.57) | 1.02 | (0.71, 1.48) |
| FVIIa-AT, pM | 46.7 | 13,029 | 36 | 2.8 | 1.02 | (0.72, 1.44) | 0.86 | (0.58, 1.26) |
| FXI antigen, % | 30.3 | 16,699 | 48 | 2.9 | 0.95 | (0.70, 1.28) | 0.88 | (0.64, 1.21) |
| Peak thrombin generation, nM | 131.9 | 16,071 | 48 | 3.0 | 1.04 | (0.76, 1.41) | 1.13 | (0.83, 1.55) |
| Platelet count, ×109 L−1 | 63.4 | 16,998 | 51 | 3.0 | 1.27 | (0.97, 1.66) | 1.19 | (0.91, 1.57) |
| Mixed Dementia | ||||||||
| Fibrinogen, mg/dL | 62.8 | 17,199 | 139 | 8.1 | 1.01 | (0.85, 1.20) | 0.99 | (0.83, 1.19) |
| FVIIc, % | 23.3 | 17,024 | 135 | 7.9 | 1.00 | (0.83, 1.20) | 1.07 | (0.87, 1.31) |
| FVIIa, mU mL−1 | 23.1 | 12,920 | 106 | 8.2 | 1.07 | (0.88, 1.31) | 1.09 | (0.88, 1.34) |
| FVIIa-AT, pM | 46.7 | 13,029 | 107 | 8.2 | 1.06 | (0.87, 1.30) | 1.06 | (0.86, 1.32) |
| FXI antigen, % | 30.3 | 16,699 | 136 | 8.1 | 1.02 | (0.85, 1.21) | 1.01 | (0.84, 1.21) |
| Peak thrombin generation, nM | 131.9 | 16,071 | 128 | 8.0 | 1.08 | (0.89, 1.31) | 1.12 | (0.92, 1.36) |
| Platelet count, ×109 L−1 | 63.4 | 16,998 | 137 | 8.1 | 0.84 | (0.70, 1.01) | 0.85 | (0.71, 1.03) |
CI = confidence interval; FVIIc = factor VII coagulant activity; FVIIa = activated factor VII; FVIIa-AT = factor VIIa-antithrombin; FXI = factor XI antigen; HR = hazard ratio; SD = standard deviation
a
Model 1 adjusted for age, sex, education, race, and field center
b
Model 2 adjusted for model 1 covariates + BMI, physical activity, alcohol intake, current and former smoking, hormone therapy use (in women only), prevalent diabetes, prevalent coronary heart disease, systolic blood pressure, hypertensive medication use, total cholesterol, APOE genotype.